IMMUNOLOGY

III B.Sc., SEMESTER-V MAIN CORE-7: IMMUNOLOGY Unit I

Types of immunity: Innate and acquired, Passive and active.

Types of immunity: Innate and acquired, Passive and active.

Lymphoid organs: Primary and secondary lymphoid organs-

Thymus

bone marrow

bursa fabricius

spleen

lymph node

GALT & BALT

Lymphocytes: Macrophages, T and B cells –origin

Lymphocytes: Macrophages, T and B cells –origin

Lymphocytes: Macrophages, T and B cells –origin

Lymphocytes: differentiation and functions

Role of lymphokines and cytokines in an immune response

Unit II

Antigen

Super Antigen

haptens

Immunoglobulin: structure, types & functions

Genetic basis of Antibody diversity.

Vaccines and Toxoids

Unit III

Acquired Immune Response: Primary and Secondary immune response.

Humoral immunity

Antigen recognition

cell interactions

clonal proliferation

interleukins

antibody synthesis

regulation of antibody synthesis

Cell mediated immunity: Role of cyototoxic T lymphocytes

Cell mediated immunity TD cells

Cell mediated immunity NK cells

Cell mediated immunity  Macrophages

Immunity to infection: Mechanism

Antigenic drift, antigenic shift

antigen

Unit IV

HLA: structure & functions

Organ transplantation

HLA typing

Autoimmunity: Concept, mechanism

Autoimmune diseases

Graves disease

SLE

serum sickness

Rheumatoid arthritis

Hypersensitivity: Definition, mechanism & types

Tumor immunology: Tumor antigens immune surveillance

Tumor antigens immune surveillance

Tumor immunotherapy.

Unit V

Immunological techniques : Production of antisera

Aggulation

Precipitation reactions

Immunoflorescence

Immunodiffusion

Immunoelectrophoresis

RIA

ELSAFISH